Twitter posts by Bio Balance -How To Change Pharmacology
- The net shift also accommodates the phenomena of "spare receptors" - http://www.bio-balance.com/Lanzara_Pharm1.htm … (see middle of the page)
- The calculation of the net shift has been applied to receptor desensitization https://www.google.com/patents/US5597699?dq=ininventor:%22Richard+G.+Lanzara%22&hl=en&sa=X&ved=0ahUKEwi2irjV_pjVAhUDND4KHdQHBVAQ6AEINjAC … and modulation https://www.google.com/patents/US8666671?dq=ininventor:%22Richard+G.+Lanzara%22&hl=en&sa=X&ved=0ahUKEwi2irjV_pjVAhUDND4KHdQHBVAQ6AEIPTAD …
- The details of the molecular work are here - http://www.bio-balance.com/GPCR_Activation.pdf … and here https://scholar.google.com/scholar?q=Molecular+dynamics+of+a+biophysical+model+for+%CE%B22-adrenergic+and+G+protein-coupled+receptor+activation&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ved=0ahUKEwiU5tGU_pjVAhXIgj4KHUE6AWEQgQMIJjAA …
- The molecular details underlying this net shift result from an electrostatic difference, which has unequal binding by agonist ligands.
- The basic derivation of this for the receptor response is shown here - http://www.bio-balance.com/Graphics.htm
- Since it is also true for our senses and the sensory receptors, it can be seen that the net shift serves as a useful biophysical description for the response.
- This is also true for such physiological responses that obey Weber's law - http://www.bio-balance.com/Weber's_Law.pdf
- Just as for a simple balance with weights -the fractional or proportional weight doesn't correlate with the response of the balance.
- The problem with pharmacology is that the fractional or proportional change in receptor states is not the true measure for the response.
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