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Friday, July 21, 2017

The problem with pharmacology is that the fractional or proportional change in receptor states is not the true measure for the response.



  1.   Jul 20
    The problem with pharmacology is that the fractional or proportional change in receptor states is not the true measure for the response.
    2 retweets



  2.   Retweeted
      Jul 20
    Just as for a simple balance with weights -the fractional or proportional weight doesn't correlate with the response of the balance.
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  3.   Retweeted
      Jul 20
    This is also true for such physiological responses that obey Weber's law -
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  4.   Retweeted
      Jul 20
    Since it is also true for our senses and their receptors, it can be seen that the net shift provides a biophysical explanation for the response.
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  5.   Retweeted
      Jul 20
    The basic derivation of this for the receptor response is shown here -
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  6.   Retweeted
      Jul 20
    The molecular details underlying this net shift result from an electrostatic difference, which increases the binding by agonist ligands.
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  7.   Retweeted
      Jul 20
    The details of the molecular work are here - &
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  8.   Retweeted
      Jul 20
    The calculation of the net shift has been applied to receptor desensitization & modulation
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  9.   Retweeted
      Jul 20
    The net shift also accommodates the phenomena of "spare receptors" - (see middle of the page)
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  10.   Retweeted
      13 hours ago
    "Bio Balance" is attempting to change pharmacology by calculating the "net shift" -



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