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Wednesday, July 30, 2008

Calming the Financial Markets

The Congress, Federal Reserve and Treasury Department want to calm the financial markets. One thing that would go a long way to calming these markets is to insure that any and all depositors are fully insured. This would reduce depositors fear that they will not be insured if their accounts are over $100,000 and would also reduce the banks bureaucracy regarding depositors having multiple accounts. This may also strengthen the banks deposits, because depositors wouldn’t have to move their money elsewhere in order to insure that they’re covered by the FDIC.

Tuesday, July 29, 2008

Enhanced Pharmaceuticals, GPCRs, Drug Safety

At Enhanced Pharmaceuticals, we’ve discovered that the rather simple act of combining an agonist with the proper amount of an antagonist allows for a general decrease in the observed drug-receptor desensitization, tachyphylaxis or tolerance. This modulation of the receptor response appears to be a quite general phenomenon applicable to many G Protein-Coupled Receptors (GPCRs), but because it is an unexpected result that differs from most pharmacological theories and clinical intuition, it hasn’t caught on in the last 16 years since the filing of my first patent on September 30, 1992. Although it was previously reported for the opioid and nicotinic receptors, no other research group has characterized and defined their experimental results using predictive biophysical and pharmacodynamic models as we have.

Although at least three companies including Enhanced Pharmaceuticals were formed around such findings, general pharmacological science has been rather slow to follow up on these findings. Truthfully, this puzzles me, because these findings represent a paradigm shift in the pharmacology field toward discovering and making safer and more effective drugs. Big pharma appears to be looking in all the wrong places to extend their patent franchises while ignoring or remaining unaware of technologies such as ours to improve their drugs.

There remains more experimental work to do, but from our studies it appears that these agonist/antagonist drug combinations work well in animals that desensitize differently and that they appear to work after desensitizing a targeted receptor system such as for the Guinea-pig trachea (an accepted experimental system for asthma studies). In our animal studies, there were also less cardiac arrhythmias with our drug combinations than with the agonist (activating) drugs alone. These studies are promising, but need further research. Because our work holds such promise for better asthma, heart failure and Parkinson drugs, we continue to hope that investors will see our potential and rise to the opportunities.

Richard G. Lanzara, M.P.H., Ph.D.
President Enhanced Pharmaceuticals, Inc.

Friday, July 25, 2008

Enhanced Pharmaceuticals

Recently, there was a blog about our company, Enhanced Pharmaceuticals, that elegantly described our technology and the hurdles that it faces for future development.

See -

I couldn’t have said it better.

My wife, who is a doctor, suggests that I need a better way to describe this technology to the public. She has suggested that I use the example of a heroine addict who uses more and more heroine, but achieves less and less of an effect from the drug. Our research suggests that by using a specific combination of heroine and an anti-heroine drug, the effect of the heroine can be maintained and not diminished through continued use.

This research requires additional work, but it holds great promise for designing safer and more effective drugs that target receptors. In our research, we’ve found this to be a general phenomenon for a number of commonly used drugs (usually called G Protein-Coupled Receptor, GPCR, activating drugs, which comprise over 30% of all pharmaceuticals). These drugs include the drugs used to treat asthma, shock, heart failure and Parkinson’s disease among others. So the potential is vast, but alas our funding isn’t.

Anyone wishing to invest in this important venture should contact me at for further details.

Sunday, July 13, 2008

Evidence for a free thiol necessary for GPCR activation

P2Y12, a G protein-coupled receptor that plays a central role in platelet activation is the receptor targeted by the antithrombotic drug, clopidogrel. The mechanism of action of clopidogrel involved cysteine 97 within the first extracellular loop of P2Y12. This provides supporting evidence for a free thiol or sulfhydryl group necessary for GPCR activation.

See - and

Friday, July 4, 2008

Esmin Green

Having worked in health care for more than two decades, I can say that a fundamental requirement is that all health care workers should have a minimum level of compassion for their fellow human beings. The video of Esmin Green shows no compassion for her. Unfortunately there are those health care workers who don’t seem to have this very basic requirement. All too often I’ve seen health care providers at all levels who do not appear to have the necessary compassion for their patients that translates into good patient care. We need more effective methods to remove them if we are to ever improve our current health care system.
Richard G. Lanzara, MPH, Ph.D.