Search This Blog

Friday, July 21, 2017

The problem with pharmacology is that the fractional or proportional change in receptor states is not the true measure for the response.



  1. The problem with pharmacology is that the fractional or proportional change in receptor states is not the true measure for the response.
  2.   Retweeted
    Just as for a simple balance with weights -the fractional or proportional weight doesn't correlate with the response of the balance.
  3.   Retweeted
    This is true for such physiological responses that obey Weber's law -
  4.   Retweeted
    Since it is also true for our senses & the response of these sensory receptors, it can be seen to be the net shift as the response.
  5.   Retweeted
    The basic derivation of this for the receptor response is shown here -
  6.   Retweeted
    The molecular details underlying this net shift result from an electrostatic difference, which is increased by agonist ligands.
  7.   Retweeted
    The net shift also accommodates the phenomena of "spare receptors" - (see middle of the page)