Calling for Pharmacologists, Cell Biologists and Those Working in Cellular Signaling

Calling all pharmacologists, cell biologists and those working in cellular signaling to test agonist/antagonist combinations for their ability to reduce or prevent receptor tachyphylaxis, desensitization or tolerance. It is important to the field of pharmacology that the simple act of combining an antagonist with an agonist reduces receptor desensitization be independently tested. Those with suitable experimental systems that demonstrate receptor desensitization, tachyphylaxis or tolerance should consider testing agonist/antagonist combinations against the responses observed with the agonist alone.