Interesting Links on Receptor Musings: End Human Trafficking Links

Interesting Links on Receptor Musings: End Human Trafficking Links

End Human Trafficking Links

Ending Human Slavery in Our Lifetimes
I’d like to believe that there is a science to ending human slavery in our lifetimes. If not, then I’d like to begin such a process. Certainly the power of the internet could be harnessed to fight against such barbarity.

The Sex Slave Industry:

The sex slave industry is one of the problems that contributes to human slavery (for some important links regarding this problem, see Stella Rotaru http://www.google.com/search?hl=en&suggon=0&as_q=&as_epq=Stella+Rotaru&as_oq=&as_eq=&num=10&lr=&as_filetype=&ft=i&as_sitesearch=&as_qdr=all&as_rights=&as_occt=any&cr=&as_nlo=&as_nhi=&safe=off). By calling attention to this problem, which exists everywhere, yes everywhere, you may be able to put press on lawmakers and others to raise the awareness of such problems and begin processes to end it.

Human Trafficking:

Sites that can serve as beginning points for understanding the aspects of human trafficking are: http://www.outreachworld.org/resource.asp?curriculumid=1141 and http://www.google.com/search?hl=en&suggon=0&as_q=Human+trafficking&as_epq=human+slavery&as_oq=&as_eq=&num=10&lr=&as_filetype=&ft=i&as_sitesearch=&as_qdr=all&as_rights=&as_occt=any&cr=&as_nlo=&as_nhi=&safe=off

How to Stop Human Trafficking:

Although there are several sites suggesting ways to combat human trafficking, we need a higher level of response from everyone. Some sites that suggest ways to stop human trafficking are: http://www.google.com/search?q=how+to+stop+Human+trafficking+%22human+slavery%22&hl=en&lr=&safe=off&tbo=1&output=search&source=lnt&tbs=qdr:y&sa=X&ei=BOZrTaLiAsL78Aa3_oXsCw&ved=0CAgQpwUoBQ&bav=on.1,or.&ech=1ψ=_OVrTcKnHMP68AbQjO3eCw12989168821933&emsg=NCSR&noj=1&ei=_OVrTcKnHMP68AbQjO3eCw . If you send anyone resources to stop human slavery or trafficking be sure to follow up and see whether or not your contribution is doing what you thought it was designed to do. Following up is very important whenever you give to charities or other causes, because unfortunately, there are always those who try to profit from others misfortunes.

Hopefully this can be the start of a resource for people committed to ending human slavery.

American Business: Innovation and Entrepreneurship

American business innovation and entrepreneurship is alive in America and it can take many forms. Here is a list of a dozen of them:

1) Prod4ever - Website design: http://www.prod4ever.com/index.html
2) MobiFlex - Building Mobile Apps Online: http://mobiflex.me/
3) Pacific Western Wood - Wood Products: http://www.pacificwesternwoodproducts.com/index.php/about-us/
4) Greg Lanzara - Artist: http://www.linkedin.com/pub/greg-lanzara/11/390/138
5) Changeling Studios - Toy and Prototype painting: http://www.changelingstudio.com/
6) Beauty Feast - Band: http://www.youtube.com/watch?v=8aefCPnPhOE&feature=related
7) Dream Homes by Nancy - Pasadena & San Fernando California Realtor: http://www.dreamhomesbynancy.com/
8) Richard J. Lanzara - Author: http://tinyurl.com/25nek7s
9) Double 8 Foods - The Neighborhood Store Indianapolis: http://www.double8foods.com/
10) Artistic Veil - wedding veil design: http://www.artisticveil.com/
11) Enhanced Pharmaceuticals - Creating safer, more effective drugs: http://www.bio-balance.com/COMPANY.htm
12) Bio Balance, Inc. - Biophysical descriptions of drug-receptor interactions: http://www.bio-balance.com/Linker.htm

Experimenting with Tweets

Experimenting with a couple of tweets:

Google Scholar - agonist/antagonist combination - receptor desensitization #Google #science #pharmacology #medicine

A pH dependent electrostatic-mechanism for receptor response? #science #pharmacology #biology #nanotech #biotech

A two-state receptor model that accounts for receptor modulation

A two-state receptor model that accounts for receptor modulation - http://www.bio-balance.com/A_Question_of_Balance_files/image080.png

My Twitter Mini Review of Pharmacology

Perhaps I need to write the story of how receptors work on Twitter? Humm, which hashtag(s) to use? - #receptor #pharmacology #science

Work at the turn of the last century summarized at - http://ow.ly/R8Hl led to the lock & key concept #receptor #pharmacology #science

Here's a modern version of the "lock and key concept" for the receptor response - http://ow.ly/R8KN #receptor #pharmacology #science

One problem is how does the binding of a small molecule alter the conformation of a much larger one? #receptor #pharmacology #science

Another problem is how do some binding molecules produce a partial or no response? #receptor #pharmacology #science

These problems & desensitization, fade or tachyphylaxis led to the two state theory - http://ow.ly/R8VQ #receptor #pharmacology

Two state mathematics only solved for the fractional or proportional change - http://ow.ly/R91A #receptor #pharmacology #science

Experiments showing an increased response with increased receptor expression didn't fit with 2 state theory #receptor #pharmacology #science

Also no consensus on what the two states of the receptor are -just active & inactive? #receptor #pharmacology #science

I suggested an alternative math to remove these problems with 2 state theory - http://ow.ly/R9jj #receptor #pharmacology #science

The idea was that the net shift could explain a binding molecule's preference - http://ow.ly/R9qX #receptor #pharmacology #science

The "net shift" (delta RH) could fit many classical dose-response curves - http://ow.ly/R9tj #receptor #pharmacology #science

We proposed that a free thiol produced the 2 (acid-base) receptor states - http://cogprints.org/4095/ #receptor #pharmacology

This was a mechanistic hypothesis of receptor function involving sulfhydryl modulation and redox regulation #receptor #pharmacology #science

This also fit nicely with the "net shift" producing the active state of the receptor #receptor #pharmacology #science

Subsequent work seems to support our observations - http://ow.ly/R9PR #receptor #pharmacology #science

Although much more work remains, it looks promising that a free thiol may explain many receptor responses #receptor #pharmacology #science

receptor activation thiol OR sulfhydryl "two state" - http://ow.ly/R9WI #receptor #pharmacology #science

@davidperrey Never seen a review by Twitter before! @rlanzara is trying it using these hashtags - check it out: #receptor #pharmacology #science

For my very mini (and biased) review of pharmacology - http://ow.ly/Rab6 #receptor #pharmacology #science

Bio Balance - Reference Library - http://www.bio-balance.com/Ref.htm

A New Exploration Into Science

Since we only know reality through our senses, we should understand how they work in order to understand how our brains work and since our receptors are the molecules that allow our senses to work, we should understand how our receptors work. Surprisingly, the chemical equilibrium of our receptors may function very much like that of a chemical balance poised between two chemical states ( http://www.bio-balance.com/Receptor1.htm ).

This picture is less complex than others have imagined, but it holds promise to understand and simplify many complex and intertwining realms such as where biology, physics and chemistry intersect. How we relate through our senses and bodies to the physical, chemical and biological realms of our world is certainly a worthwhile endeavor to discover. The tools we need to understand these concepts require nothing more than our initial curiosity, patience and some high school algebra.

The physical foundation begins with the study of a simple two pan balance. Although my and most people’s initial reaction is that most everything is already know about the simple balance so what could it possibly have to do with understanding our senses or the world? In fact, if we examine the ways that a balance can be balanced, we find that there are two ways to establish balance. This in and of itself may not seem like much of a breakthrough observation, but by combining and solving for a shift in the mass (weight) from one side to the other we can derive a fundamental equation of equilibrium ( http://tinyurl.com/b8u2vg ) that can be used to understand how our senses function ( http://tinyurl.com/bkf8yb ).

Understanding these concepts is the beginning of understanding how it could be that the receptor process bends the sensory function by a ratio-preserving compression and thereby permits the coupling of the organism to such dynamic ranges of stimuli. By linking these concepts to the chemical concept of Langmuir binding of a chemical entity such as a drug or molecule to another molecule such as a receptor, we can derive mathematical expressions that represent pharmacological dose-response curves ( http://www.bio-balance.com/Graphics.htm ).

Deriving these expressions requires no more than some careful algebra, but leads to several important insights about the physical, chemical and biological relationships that govern how our sensory receptors “see” the world. It turns out that we don’t sense the world in a linear way, which means that we tend to underestimate both the small and larger ends of the stimulus response curve. Perhaps it is in these realms where our senses are not ideal for detecting changes that we may find a better or more accurate understanding of the universe in which we live.