Interesting Links on Receptor Musings: Complexities in Understanding Our Receptors and How We View the Universe...

Interesting Links on Receptor Musings: Complexities in Understanding Our Receptors and How We View the Universe...

Complexities in Understanding Our Receptors and How We View the Universe...

Previously I mentioned that there exists a devilish complexity in the vast array of chemical and biological modifications that can alter the free thiol or sulfhydryl group, which is the reactive group of the essential amino acid, cysteine, in many important biological proteins (http://ombamltine.blogspot.com/2008/05/devilish-complexity-of-cysteine.html). Thiol groups are vitally important for their ability to form disulfide bonds with other thiol groups and to form either reduced or oxidized (redox) forms as well as oscillating between acid and base states (http://ombamltine.blogspot.com/2008/05/beta-adrenergic-receptor-in-two.html). Any one of these forms may further interact reversibly or irreversibly with a panoply of other chemical and biological molecules. Since most all of the G protein-coupled receptors (GPCRs) that have been studied have thiol (http://ombamltine.blogspot.com/2008/07/evidence-for-free-thiol-necessary-for.html) or disulfide (two thiols linked together) groups, this creates a very complicated picture to understand these receptors’ active and inactive states (http://ombamltine.blogspot.com/2008/08/active-and-inactive-receptor-states.html). This is important in order not only to understand how these receptors work, but to understand how we sense reality (http://ombamltine.blogspot.com/2009/06/how-we-sense-reality-no-really.html) since our sensory receptors are GPCRs. These are also the receptors that are targets of over fifty percent of our pharmaceutical drugs. Understanding how our receptors work at the molecular level is an awe inspiring undertaking, because these are the molecules that link our thoughts and senses to the universe. Understanding how they function may open new frontiers for us to truly understand our place in the cosmos.

Interesting Links on Receptor Musings: End Human Trafficking Links

Interesting Links on Receptor Musings: End Human Trafficking Links

End Human Trafficking Links

Ending Human Slavery in Our Lifetimes
I’d like to believe that there is a science to ending human slavery in our lifetimes. If not, then I’d like to begin such a process. Certainly the power of the internet could be harnessed to fight against such barbarity.

The Sex Slave Industry:

The sex slave industry is one of the problems that contributes to human slavery (for some important links regarding this problem, see Stella Rotaru http://www.google.com/search?hl=en&suggon=0&as_q=&as_epq=Stella+Rotaru&as_oq=&as_eq=&num=10&lr=&as_filetype=&ft=i&as_sitesearch=&as_qdr=all&as_rights=&as_occt=any&cr=&as_nlo=&as_nhi=&safe=off). By calling attention to this problem, which exists everywhere, yes everywhere, you may be able to put press on lawmakers and others to raise the awareness of such problems and begin processes to end it.

Human Trafficking:

Sites that can serve as beginning points for understanding the aspects of human trafficking are: http://www.outreachworld.org/resource.asp?curriculumid=1141 and http://www.google.com/search?hl=en&suggon=0&as_q=Human+trafficking&as_epq=human+slavery&as_oq=&as_eq=&num=10&lr=&as_filetype=&ft=i&as_sitesearch=&as_qdr=all&as_rights=&as_occt=any&cr=&as_nlo=&as_nhi=&safe=off

How to Stop Human Trafficking:

Although there are several sites suggesting ways to combat human trafficking, we need a higher level of response from everyone. Some sites that suggest ways to stop human trafficking are: http://www.google.com/search?q=how+to+stop+Human+trafficking+%22human+slavery%22&hl=en&lr=&safe=off&tbo=1&output=search&source=lnt&tbs=qdr:y&sa=X&ei=BOZrTaLiAsL78Aa3_oXsCw&ved=0CAgQpwUoBQ&bav=on.1,or.&ech=1ψ=_OVrTcKnHMP68AbQjO3eCw12989168821933&emsg=NCSR&noj=1&ei=_OVrTcKnHMP68AbQjO3eCw . If you send anyone resources to stop human slavery or trafficking be sure to follow up and see whether or not your contribution is doing what you thought it was designed to do. Following up is very important whenever you give to charities or other causes, because unfortunately, there are always those who try to profit from others misfortunes.

Hopefully this can be the start of a resource for people committed to ending human slavery.

American Business: Innovation and Entrepreneurship

American business innovation and entrepreneurship is alive in America and it can take many forms. Here is a list of a dozen of them:

1) Prod4ever - Website design: http://www.prod4ever.com/index.html
2) MobiFlex - Building Mobile Apps Online: http://mobiflex.me/
3) Pacific Western Wood - Wood Products: http://www.pacificwesternwoodproducts.com/index.php/about-us/
4) Greg Lanzara - Artist: http://www.linkedin.com/pub/greg-lanzara/11/390/138
5) Changeling Studios - Toy and Prototype painting: http://www.changelingstudio.com/
6) Beauty Feast - Band: http://www.youtube.com/watch?v=8aefCPnPhOE&feature=related
7) Dream Homes by Nancy - Pasadena & San Fernando California Realtor: http://www.dreamhomesbynancy.com/
8) Richard J. Lanzara - Author: http://tinyurl.com/25nek7s
9) Double 8 Foods - The Neighborhood Store Indianapolis: http://www.double8foods.com/
10) Artistic Veil - wedding veil design: http://www.artisticveil.com/
11) Enhanced Pharmaceuticals - Creating safer, more effective drugs: http://www.bio-balance.com/COMPANY.htm
12) Bio Balance, Inc. - Biophysical descriptions of drug-receptor interactions: http://www.bio-balance.com/Linker.htm

Experimenting with Tweets

Experimenting with a couple of tweets:

Google Scholar - agonist/antagonist combination - receptor desensitization #Google #science #pharmacology #medicine

A pH dependent electrostatic-mechanism for receptor response? #science #pharmacology #biology #nanotech #biotech

A two-state receptor model that accounts for receptor modulation

A two-state receptor model that accounts for receptor modulation - http://www.bio-balance.com/A_Question_of_Balance_files/image080.png